Assessment of how oxidative stress affects mtDNA in liver injury, especially in cholestasis, is of crucial importance because more mtDNA in hepatocytes and other liver cells is associated with a high number of mitochondria (approximately 1,0002,000) than in white cells, which have approximately 30100 mitochondria
1 Introduction - glutathione and ChaC-like proteins Glutathione (GSH), a tripeptide of -glutamylcysteinylglycine, is a key component of the thiol system and plays a vital role in maintaining cellular redox balance across compartments, tissues, and organisms
All of the velocities are given by Michaelis-Menten kinetics, with the K m values taken from the literature, and where available, from human data
One study found that vitamin C plays an important role in restoring depleted glutathione levels (4)