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Whilst there is a range of possibilities that would require large-scale investigation, the authors also hypothesize that these discrepancies arise as women are less likely to have insulin abnormalities and are less susceptible to its detrimental effects

The result is a bioavailability profile sufficient to drive clinically meaningful weight loss, something the scientific community long considered impossible for peptide-based GLP-1s

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This addition targets systemic inflammation through NF-kB inhibition, fundamentally changing the therapeutic profile