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Patients should contact their GP or diabetes specialist nurse if: Gastrointestinal side effects persist beyond the first few weeks or significantly impact quality of life They experience signs of dehydration due to vomiting or diarrhoea They have recurrent hypoglycaemia They develop visual changes or symptoms of gallbladder disease (e.g., right upper abdominal pain) Any new or concerning symptoms develop Regular monitoring of HbA1c, renal function, and body weight is recommended during treatment with Rybelsus

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In the muscle atrophy mouse model, Ex-4 also increased muscle mass and muscle fiber size and improved muscle function