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Without specific proof as to the exact cause of why a GLP-1 could cause a higher risk of developing NAION, we can hypothesize a bit and suggest hypovolemia and dehydration from perhaps weight loss, especially if the patient is getting a medication for hypertension and the weight loss has reduced the need for the hypertensive agent and thus the patient develops hypotension
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Phase 2 obesity data published in The New England Journal of Medicine showed large average weight reductions, which helped establish retatrutide as one of the most closely watched next-generation obesity drugs in development
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