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However, we did find a small increased risk of NAION with exenatide use when using the specific NAION definition. Future research should incorporate ocular risk factors or examine dose-dependent effects to continue to investigate a potential causal relationship between semaglutide and NAION, they added

1111,1117 Direct gene therapies involve the delivery of full gene copies to restore deficient expression, as observed with the use of AAV vectors for spinal muscular atrophy

Some research suggests GLP-1 medications may benefit patients with cardiovascular disease by lowering blood pressure, improving cholesterol, and reducing inflammation

For instance, a study by Grace et al., on lambs receiving a single 2 mg subcutaneous B12 injection demonstrated significant increases in serum and liver B12 concentrations for up to 24 days compared to untreated animals (2)