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All of these studies are hypothesis-generating and await confirmation in RCTs. According to Lane, the rationale for GLP-1 receptor agonists in lupus stems from the drugs demonstrating anti-inflammatory properties, potentially by inhibiting the NF-B pathway, which plays a crucial role in inflammation

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These murine models were initially presented with corticosteroids, which reportedly contributed to severe muscular damage in these murine models

However, a wholesale list price reduction for Wegovy has been announced, bringing the cost to $675 for covered patients, beginning January 1, 2027