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Tirzepatide decreases oral contraceptive exposure by about 20%, which increases the risk of pregnancy
Restoring mitochondrial biogenesis with metformin attenuates -GP-induced phenotypic transformation of VSMCs into an osteogenic phenotype via inhibition of PDK4/oxidative stress-mediated apoptosis
Side Effects and Tolerability Profiles Both medications share common GLP-1 class side effects including nausea, vomiting, constipation, and mild diarrhea, particularly during dose escalation phases
For patients with a history of pancreatitis, FDA labeling advises considering other antidiabetic or weight management therapies, though this is not a formal contraindication
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