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General function: Involved in nicotinamide N-methyltransferase activity Specific function: Putative nicotinamide N-methyltransferase involved in rDNA silencing and in lifespan determination Gene Name: NNT1 Uniprot ID: Q05874 Molecular weight: 29632.30078 Reactions General function: Involved in phosphatidylethanolamine N-methyltransferas Specific function: S-adenosyl-L-methionine + phosphatidylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine Gene Name: PEM1 Uniprot ID: P05374 Molecular weight: 101203.0 Reactions General function: Involved in identical protein binding Specific function: Specifically methylates guanosine-37 in various tRNAs

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Front Aging Neurosci

Moreover, IGFBP-1 inhibition in cancer cells also blocked angiogenesis in HUVECs treated with conditioned medium (42)