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Discovery of Ketosteroid Isomerase In 1955 Talalay and Wang discovered a new enzymatic reaction involving ketosteroids, including 5-androsten-3,17-dione (5-AD) and 5-pregnen-3,20-dione (5-PD), and purified a highly active isomerase from Pseudomonas bacteria (Talalay and Wang, 1955)

Additionally, GLP-1 receptor activation indirectly suppresses hepatic de novo lipogenesis through downregulation of lipogenic transcription factors and enzymes, independent of weight loss [29]