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It is characterized by the persistent presence of pro-inflammatory cytokines, oxidative stress, and immune dysregulation

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In a follow up study with lower, sub-anorectic doses of GLP-1 (0.4 pmol/kg/min), glucagon (2.8 pmol/kg/min), GLP-1 + glucagon combination at the same doses, or placebo for 120 minutes we showed that there was a 13% decrease in food intake after the combination, with the individual infusions having no significant effect (67), further supporting the concept of co-agonism with these hormones

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