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Methods In this retrospective cohort study, 125 474 adults with overweight or obesity newly initiated treatment with a dual-labeled GLP-1 RA (liraglutide, semaglutide, or tirzepatide) between January 1, 2018, and December 31, 2023, with a baseline body mass index of 27 or more, an available weight measurement within 60 days before initiation, and regular care in the year before initiation were identified using electronic health record data from a collective of US health care systems

It works by boosting insulin release in response to high blood sugar levels following a meal and lowering sugar production by the liver

Lifestyle still matters: These medicines work best with healthy eating, regular physical activity, adequate sleep, and stress management

This is the most common ruin-your-medication scenario