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The direct role of Vit B12 is to serve as a co-factor in the methylation reaction of Hcy to methionine acting in synergy with the enzyme: Methionine Synthetase (MS) which would integrate methionine via a series of reactions and serves to produce S-adenosyl-methionine (SAM), a major methyl donor for several methylation pathways (Fig

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This framework enabled structured synthesis and comparative interpretation of data across studies