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Using this strategy, we were able to identify three chemically distinct GLP-1R agonist candidates from large compound libraries: GQB47810 (non-peptidic small molecule), DPDPE (an endorphin-derived peptide), and neuromedin C, demonstrating the ability of the pipeline to capture diverse activation strategies and efficiently guide experimental validation

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While our study was observational and does not definitively confirm an association between GLP-1 medications and reduced breast cancer incidence, it does add to the growing body of evidence suggesting that its worth investigating these weight-loss drugs as potential cancer prevention tools, McDonald said