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3 Alcohol-induced hepatocyte injury and its role in HBV pathogenesis and HCC risk 3.1 Alcohol metabolism and its shift during chronic alcohol use About 90-98% of ingested alcohol is metabolized in the liver, making it the primary organ responsible for alcohol breakdown and elimination

MECHANISM CATEGORIES RESEARCH CONDITIONS SAFETY Side effects Limited published safety data Reported well-tolerated in small Russian studies Known interactions GABAergic medications (theoretical unstudied) Benzodiazepines (theoretical additive sedation) Contraindications Pregnancy/lactation (unstudied) Hypersensitivity REGULATORY STATUS FDA Not FDA-approved

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