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In some cases, a person might carry two MTHFR mutations, in which case, their body is only able to detox at a rate of 10% compared to that of someone without the mutation
Epub 2012 Nov 1
Consistent with this effect we report here the induction of -GCS-HS, the catalytic subunit of the rate limiting enzyme in GSH biosynthesis which determines a greater GSH biosynthetic capacity of mucosa 7 days after TNBS treatment
Combined with adequate protein intake (widely recommended at 1.2-1.6g per kg of body weight during GLP-1 protocols) and resistance training, the higher dose ranges may actually preserve lean mass better than lower doses, because the energy deficit is being met predominantly through fat oxidation rather than muscle catabolism
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