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Due to this mutated gene, CF patients have impaired fluid transport across the epithelial cell membranes, leading to thick and viscous mucus buildup at the cell surface, creating an environment prone to colonization and infection by opportunistic pathogens

These symptoms are typically most pronounced during the initial weeks of treatment, the first 24hr-48hrs after the injection and when dosages are increased

Gradual dose escalation, where the dosage is slowly increased, can help minimize this side effect, allowing the body to adjust more comfortably

The ad has also drawn the ire of some doctors who prescribe obesity drugs, as well as the Partnership for Safe Medicines, a coalition of nonprofit organizations including some that are affiliated with the drug industry