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The same study also illustrated that upregulation of GLP-1 via gene transfer was associated with enhanced learning and memory, providing evidence of the role GLP-1 has in hippocampal function [57]

GLP1R and amylin agonism in metabolic disease: complementary mechanisms and future opportunities

Note for guidance on the evaluation of the pharmacokinetics of medicinal products in patients with impaired renal function

Covert hepatic encephalopathy consists of minimal and grade 1 hepatic encephalopathy 1 , could impair the cognitive function, lower work efficiency, reduce the quality of life 6,7 , impair driving skills 8,9,10,11 , or results in poor prognosis 12,13,14