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Seizure medications such as phenytoin and phenobarbital, as well as diabetes medications like metformin, can lower B12 levels over time

However, some experts have raised doubts about the safety of the treatment, amid rising numbers of reported issues from people who have used it

Lastly, a 2011 European study found that EPP patients treated with MT1 experienced a higher quality of life and less pain compared with a control group [15]