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TP53 induces ferroptosis primarily by transcriptionally repressing the expression of SLC7A11 ( TP53 lead to a loss of this repression, resulting in sustained SLC7A11 activity and greater cellular resistance to ferroptosis ( 3 KR, which cannot induce cell-cycle arrest, senescence or apoptosis, fully retains the ability to suppress SLC7A11 and trigger ferroptosis under oxidative stress ( The reasons for variable expression of CHAC1 in different cancers are still unclear, but it appears to be critically dependent on TP53 status
**As the level of insurance coverage varies from company to company, treatments may or may not be covered
However, it is recommended to avoid strenuous physical activity or heavy lifting for a short period after the injections to minimize the risk of bruising or swelling at the injection site
