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However, while the half-life was extended to 68 days, making it suitable for OW dosing (56), the potency of albiglutide was significantly reduced (GLP-1R affinity of albiglutide is 20 nM compared with 0.02 nM for exenatide) (55), most likely due to a combination of the Gly8 modification and the covalent attachment to HSA
Enzyme inhibitors such as acarbose, voglibose and miglitol are used in clinical practice for the treatment of T2DM and as adjunct therapies in the treatment of T1DM (24)
Leptin, the satiety hormone, is produced by fat cells
In addition, while most group health plans (whether fully insured or self-funded) are subject to many federal laws, including the preventive-care mandates under the Affordable Care Act (learn more here), none require employers to cover GLP-1 drugs for either diabetes treatment or weight loss
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