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Conversely, a portion of uric acid is secreted back into the proximal tubular lumen through various apical transporters, including ABCG2, NPT1, NPT4, and GLUT9, along with the basolateral transporters OAT1 and OAT3

(March 2023)

Yet both of these experimental approaches can be informative to evaluate how formulation composition modulates PPIs, and thereby, viscosity, and aggregation