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Liraglutide (LEADER trial), semaglutide (SUSTAIN-6), and dulaglutide (REWIND trial) have shown significant reductions in major adverse cardiovascular events (MACE) in patients with established cardiovascular disease or multiple cardiovascular risk factors

257 As apoptosis typically helps contain the inflammatory cascade, a shift from necrosis to apoptosis in SAP may represent a beneficial adaptation that reduces disease severity