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The FDA-approved oral Wegovy (semaglutide 25 mg) is currently the only safe, proven oral GLP-1 for weight management

Combining these two can offer a range of benefits, but it is important to understand the interaction and how to manage it safely

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This is mechanistically demonstrated in breast cancer models, where SFN, by activating the Nrf2 pathway, reduces the secretion of prostaglandin E2 (PGE2) from tumor cells, thereby triggering MDSCs to switch from an immunosuppressive to an immunogenic phenotype and inhibiting their expansion (76)