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Recently, it has been shown that docosahexaenoic acid supplementation in porcine oocytes during IVM can improve AMPK regulation, upregulate the relative expression of genes related to mitochondrial potential and lipid metabolism, increase the levels of fatty acids and lipid droplets in mature oocytes, and promote an increase in ATP synthesis, further improving mitochondrial function and lipid metabolism to enhance homeostasis of energy metabolism, thereby improving the quality of mature oocytes and enhancing the embryonic developmental potential of IVP embryos [101]
Notably, EV-associated DAMPs have been found in stored red blood concentrates [238], suggesting that eryptosis-mediated generation of EVs might exert immunomodulatory DAMP-triggered effects
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