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In this regard, most studies look at berberines effects on nonalcoholic fatty liver disease, but inflammation is also a critical part of conditions like heart disease and diabetes.12 17 Notably, a 2020 meta-analysis found significant reductions in CRP (C-reactive protein, a major marker of inflammation) in patients taking berberine.18 A 2024 review of randomized controlled trials corroborated the findings of the 2020 meta-analysis.53 For diabetes care One of the few things we can almost conclusively say berberine supports is diabetic care
This opens an opportunity for oral small-molecule therapies that target the well-validated GLP-1R for metabolic health
it has to be supplied in sufficient amounts in the diet
Body composition tools are especially useful, as they separate fat mass, lean muscle, and water weight instead of relying on total body weight alone
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