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The following groups of people are at a greater risk of developing a vitamin B12 deficiency: Vegans or vegetarians People 75+ years Having a digestive system disorder like Crohns or celiac disease Drinking excessive amounts of alcohol Having Sjgrens syndrome Taking certain medications like oral birth control or metformin Common symptoms of a vitamin deficiency include fatigue, numbness, poor balance, memory loss, and breathlessness

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Figure 2 4.1 Imaging of Gln metabolism predicts treatment response Abnormal Gln metabolism has facilitated the use of non-invasive imaging techniques for early tumor diagnosis and treatment monitoring, such as 18F-(2S,4R)-4-fluoroglutamine (18F-FGln) PET and L-( 18F-FGln and 11C-Gln are imaging agents used for assessing Gln metabolism in tumors