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Diverse naturally occurring compounds and dietary supplements (such as polyphenols, flavonoids, carotenoids etc) have been reported to be endowed with chemopreventive and angiopreventive activities in PCa [12, 13], by targeting multiple pathways, thus interfering with cancer insurgence, progression and metastasis [12,13,14,15]
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While the cells treated with Ru(II)-OH or NP2 in a 1% O 2 atmosphere were confluent and alive, the cell treated with NP4 had a strongly reduced cell population and a mixture of living and dead cells comparable to the treatment with these nanoparticles in a 21% O 2 atmosphere (Fig
