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Preclinical studies in animal models have demonstrated that survodutide effectively activates both GLP-1R and GCGR, resulting in reduced body weight, slower gastric emptying, decreased energy intake, increased energy expenditure, and improved glucose tolerance [86]
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62 HeitmannB
however, it can also create a reductive microenvironment that paradoxically may aid advanced tumors, reflecting the complex dual role of Nrf2 in cancer
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