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Decreased expression of GSH synthesis leads to low free GSH levels, resulting in elevated ROS, immune dysfunction, and increased disease severity in COVID-19 patients 592

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Monocyte-platelet aggregates (MPA) formed by the interaction of P-selectin/PSGL-1 leads to reactive oxygen species (ROS) production, NF-B activation, release of molecules such as monocyte chemotactic protein-1 (MCP-1), tissue factor (TF), IL-1 and IL-8 and accelerate thrombosis [38, 39]