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In PIONEER REAL Canada, the estimated change in body weight was higher at 7.17% ( 7.19 kg) [16], which was also higher than observed in the PIONEER clinical development programme, where weight loss varied between 2.6 and 4.4 kg [10,11,12,13, 24]

However, the study highlighted a critical nuance: when assessed on a grams per kilogram of body weight per day (g/kg/day) basis, average protein intake was insufficient to meet the higher needs (1.22.0 g/kg/day) recommended during weight loss

In PEGylation, polyethylene glycol (PEG) chains are attached