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Other Effects Although not significant in all studies, post-hoc analysis of the placebo-controlled studies in phase III showed that DPP-4 inhibitors slightly lower blood pressure, improve post-prandial and fasting lipemia, reduce inflammatory markers, diminish oxidative stress, improve endothelial function, and reduce platelet aggregation in type 2 diabetes (122)

Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin, in type 2 diabetes: the LEAD (Liraglutide Effect and Action in Diabetes)-2 study

Schisphenthin A and schisphenthin C exhibited moderate antiproliferative effects against HepG2 cells

Interestingly, the drug effects on the thiosulfate oxidation module were unrelated to the metabolic phenotype, as vehicle-dosed DIO mice did not show any changes in these KEGG domains compared to chow-fed controls