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200,399,400,401,402 Elevated NNMT inhibits the methylation potential of cancer cells through inducing methyl sink in the form of MNA

Typical applications include glutathione S-transferase phase-II conjugation assays, glutathione peroxidase and glutathione reductase coupled assays, GSH/GSSG ratio determination as a redox readout in cultured cells, protein S-glutathionylation studies, and ferroptosis models where glutathione availability governs glutathione peroxidase 4 activity and therefore phospholipid hydroperoxide handling (Yang et al., Cell, 2014)

Adding the glucagon component raises resting energy use

Lenzi A, Lombardo F, Gandini L, Culasso F, Dondero F