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In the solubility-based formulation, a decreasing dilution ratio results in less organic solute dissolved in the aqueous phase, thus decreasing the effective value
Clinical trial data and post-marketing surveillance have documented that gastrointestinal side effects are among the most common adverse reactions to GLP-1 receptor agonists
The column oven temperature was 50 C, the mobile phase consisted of acetonitrile-methanol-water (30:16:54 v/v, pH 45 adjusted by 0.01 N HCl), the flow rate was 1.2 ml/min and the eluate absorbance was monitored online at a wavelength of 230 nm
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