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Employing melatonin as an immunomodulatory agent therefore may require higher dosages to be effective, for example in murine models, a dose of 10mg/kg is widely used to investigate the anti-inflammatory and tissue-protective actions of melatonin (18, 2931, 70)

The overweight and obesity epidemic in the USA today resulted from multiple contributing factors, including genetic, medical, environmental, behavioral, and socioeconomic influences

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Drug metabolism and drug design The knowledge of drug metabolism is important in new drug design and development