cysteine glutathione disulfide The mediating role of 3-indoleglyoxylic acid and cysteine-glutathione Glutathione Disulfide L-Cysteine-glutathione disulfide (CYSH-GSH, L-CySSG, CAS

1 2 Fluoxetine Monograph

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Glutathiones major role is in fighting oxidative stress, a naturally occurring process in cells as a byproduct of metabolism

This approach inspired other programmes: N-hexanoic-Tyr-D-Arg : enkephalin-derived, protease-resistant, studied for pain N-methyl-Aib inclusions : N-methyl substitutions increase membrane permeability at the cost of partial loss of receptor affinity Beta-peptides and D-amino acids : substitution of natural chiral residues by their D enantiomers, making the peptide invisible to endogenous proteases while (sometimes) preserving function Stapled peptides : hydrocarbon cyclisation, popularised by Verdine (Harvard), stabilises alpha helices and improves cellular penetration These strategies progressively shift the peptide / small molecule frontier