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Statements Author contributions QG organized the article
The main barriers are bioavailability (how much drug actually enters the bloodstream), stability (peptides degrade when exposed to skin temperature and enzymes), and patient compliance (patches still require weekly changes and site monitoring)
Certain beneficial bacteria are often reduced in individuals with obesity, potentially weakening natural GLP-1 signaling
W., Muthupillai, R., Jahoor, F., Minard, C
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