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2-Hydroxyglutaric Acidurias The 2-hydroxyglutaric acidurias represents a family of related metabolic disorders that are due to the accumulation of one or the other, or both, of the stereoisomers of 2-hydroxyglutarate (2-HG), namely D-2-hydroxyglutaric acid and L-2-hydroxyglutaric acid in the blood, cerebrospinal fluid (CSF), and the urine

Rapid weight loss from any cause, including pharmacotherapy, can increase the risk of gallstone formation in patients with intact gallbladders