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Int J Mol Sci (2015) 16(9):20195211

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Second-Line Pharmacological Treatments Antidepressants Targeting Persistent Abdominal Pain Antidepressants are beneficial for IBS patients potentially due to their central effects, but most importantly due to their peripheral effects targeting underlying mechanisms, such as visceral hypersensitivity, pain perception, and motility (Ford et al., 2019)

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Foster HE, Jr., Hanno PM, Nickel JC et al: Effect of amitriptyline on symptoms in treatment nave patients with interstitial cystitis/painful bladder syndrome

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