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To increase the plasma half-life by avoiding renal elimination, GLP-1 analogs were modified by adding acyl groups (liraglutide and semaglutide) or large molecules such as albumin (albiglutide) and the Fc portion of IgG (dulaglutide)

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5 Potential role of ferroptosis in RA inflammation and tissue damage 5.1 Ferroptosis products and derivatives can act as inflammatory mediators Ferroptosis is an immunogenic form of cell death, and its metabolites and derivatives can also act as inflammatory mediators to further exacerbate RA inflammatory responses