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Severe gastrointestinal disease: Conditions like gastroparesis, inflammatory bowel disease, or severe GERD may worsen with Retatrutide

We monitor your GIP and GLP-1 receptor sensitivity to determine if a transition will break through the resistance and restart your transformation

For researchers tracking this space, the key trials to watch in 2026 include the remaining TRIUMPH program readouts for retatrutide, the GLORY-OSA trial for mazdutide in obstructive sleep apnea, and the first Phase 1 data from several quadruple-agonist programs entering clinical development

As mentioned above, Ozempic (and other GLP-1 agonists) delays the gastric emptying time after a meal