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For some patients, semaglutide may have positive effects on mental health, particularly through weight loss and improved physical health, which can enhance mood and self-esteem

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While selective activation of PPAR by fibric acid derivates (fibrates) primarily improves hepatic lipid and cholesterol metabolism 3 , the selective activation of PPAR by thiazolidinediones (TZDs) enhances insulin sensitivity in peripheral tissues such as the adipose tissue, liver and skeletal muscle 4

It carries more uncertainty than a licensed fat dissolver because it hasnt been through the same clinical evidence process, and regulators including the GPhC have warned it has potentially caused serious harm when supplied or administered without proper oversight