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This effect on iris pigmentation is well-known, mainly in glaucoma treatment

Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis

Acute Traumatic Amputation Presentation Complete or partial loss of limb/digit with visible separation or near-separation Massive hemorrhage or active bleeding at the amputation site Severe pain and neurovascular compromise distal to injury Avulsion with neurovascular bundle involvement Crush injury component (common in industrial and vehicular trauma) Shock (hemorrhagic) tachycardia, hypotension, pallor Postoperative / Chronic Amputation Status Signs Healed residual limb (stump) of variable length Phantom limb sensation or phantom limb pain Prosthesis use or fitting in progress Stump edema, skin breakdown, blistering Neuroma formation at the stump (palpable nodule, severe point tenderness) Heterotopic ossification at residual limb Amputation Stump Complications Stump infection: Erythema, warmth, purulence, fever, elevated WBC may involve superficial skin, deep soft tissue, or bone (osteomyelitis) Stump necrosis: Eschar formation, dark/black discoloration, malodor, failure of primary wound closure Wound dehiscence: Reopening of surgical closure Contact dermatitis/skin breakdown: Prosthetic socket irritation Chronic stump pain: Neuroma, bony spur, inadequate padding CDI Query Trigger When documentation mentions stump wound or wound care at residual limb, query the provider to clarify: Is this an infection (and if so, the causative organism), necrosis, or routine postoperative wound care

Clascoterone (Breezula) A topical anti-androgen that blocks DHT at the scalp without the systemic hormonal exposure of finasteride