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The gut microbiota also plays a significant role in late-phase oral NR metabolism (3 h post-administration), which is converted to NAM by the enzyme BST1, and then deamidated into NA by microbes, allowing PreissHandler synthesis by capable tissues 127
While necessary for acute survival, this response generates an enormous quantity of reactive oxygen species (ROS) as collateral damage
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And as I mentioned, some people are taking cispeptin antagonists
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