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Choose a schedule you can maintain reliablywhether that is Saturday morning before breakfast or Wednesday evening after dinner

While these effects contribute to sustained satiety and improved glycemic control, they also mean that food and prep solutions may remain in the digestive tract longer than anticipated

Even if these approaches are successful in many cases, there is still a subset (3%5% of patients) that progress to therapeutically refractive disease, constituting the so-called TC-related deaths due to the lack of effective treatment. In this view, some efforts are ongoing to identify personalized therapy for refractory patients and drug repositioning represents one of the potential alternatives (Xu et al., 2019)

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