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Metalloproteinase Balance Wound healing depends on a careful balance between matrix metalloproteinases (MMPs), which break down damaged tissue, and their inhibitors (TIMPs)

The authors administered oral Dihexa to APP/PS1 transgenic mice (a standard amyloidopathy model of Alzheimers disease) and showed that brain AngIV levels were elevated relative to wild-type after Dihexa administration, that spatial learning and memory were restored on Morris water maze testing, that hippocampal neuronal density and synaptophysin protein expression were preserved, that astrocyte and microglial activation were reduced, and that pro-inflammatory cytokines (IL-1, TNF-) decreased while anti-inflammatory IL-10 increased

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Compared to CJC-1295 DAC (tetra-substituted GHRH analog with Drug Affinity Complex, 6-8 day half-life), Tesamorelin presents a short plasma half-life of approximately 8 minutes via SC route (FDA Egrifta SV label)