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6.3 Clinical applications in cardiovascular disease prevention Recent American College of Cardiology/American Heart Association guidelines advocate for the use of GLP-1RAs in patients with T2DM at high risk of atherosclerotic cardiovascular disease (ASCVD), irrespective of well-controlled glucose levels, based on the clinical trials mandated by FDA-issued industry guidelines in December 2008 to assess the cardiovascular effects of new diabetic therapies (247)
Compounding is legally permitted primarily when FDA-approved drugs are in shortage, or when a patients unique medical need cannot be met by commercial products
Evidence of past weight loss attempts: Some plans require proof of previous diet and exercise attempts before approving GLP-1s
In Figure 2 I am showing a figure from Crawford et al., which shows data from an experiment where both wild-type (WT) and GST Knock-out mice (KO) were both exposed to aflatoxinB1
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