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Who Should Avoid Copper Peptides Most people can safely use copper peptides, but caution is warranted in certain situations: Wilson's disease or other copper metabolism disorders Known allergy to copper or peptide ingredients Active scalp infections or open wounds Pregnancy and breastfeeding (insufficient safety data) When in doubt, consult a dermatologist or healthcare provider before starting treatment

To reinforce the reliability of primary analyses, external validation was performed using data from the Chang Gung Research Database (CGRD) 55

Additionally, alterations in Ca 2+ regulation, including leaky ryanodine receptors (RyR2), were ameliorated via the recovery of Na + /Ca2 + exchanger currents

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