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A 2025 European Journal of Clinical Nutrition commentary on the NICE guideline argued that the diagnostic threshold and clinical awareness still need to be tightened further, especially around pernicious anaemia, which is still under-recognised in primary care
Pharmacological interventions such as orlistat or GLP-1 receptor agonists may be considered for patients with BMI 30 kg/m who have not achieved adequate weight loss through lifestyle measures alone
