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5 A recent meta-analysis of 764 RCTs including 421,346 people with type 2 diabetes found that both medicine classes reduced: 6 All-cause mortality Cardiovascular mortality Non-fatal myocardial infarction Kidney failure The mechanism by which these medicines reduce adverse cardiovascular outcomes remains uncertain

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Occasional headaches may occur, especially during initial treatment phases as cellular detoxification processes increase activity

(3) Johansen PB, Nowak J, Skjaerbaek C, Flyvbjerg A, Andreassen TT, Wilken M, Orskov H