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Because some - but not all - NASH patients experienced improvement with pioglitazone in previous studies, this 2017 study sought to specifically examine the relationship between pioglitazone concentrations in the blood and improvements in liver histology

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This proposal was based in part on the finding that [GSH]:[GSSG] in the secretory pathway and in microsomal vesicles is similar to the ratio found in redox buffers that are effective for the oxidative folding of proteins in vitro that is, between 1:1 and 3:1 (Bass et al , 2004